Title: Informatics and Modeling Platform for Stable Isotope-Resolve Metabolomics



Abstract: Recent advances in stable isotope-resolved metabolomics (SIRM) are enabling orders-of-magnitude increase in the number of observable metabolic traits (a metabolic phenotype) for a given organism or community of organisms.  Analytical experiments that take only a few minutes to perform can detect stable isotope-labeled variants of thousands of metabolites.  Thus, unique metabolic phenotypes may be observable for almost all significant biological states, biological processes, and perturbations.  Currently, the major bottleneck is the lack of data analysis that can properly organize and interpret this mountain of phenotypic data as highly insightful biochemical and biological information for a wide range of biological research applications.  To address this limitation, we are developing bioinformatic, biostatistical, and systems biochemical tools, implemented in an integrated data analysis platform, that will directly model metabolic networks as complex inverse problems that are optimized and verified by experimental metabolomics data.  This integrated data analysis platform will enable a broad application of SIRM from the discovery of specific metabolic phenotypes representing biological states of interest to a mechanism-based understanding of a wide range of biological processes with particular metabolic phenotypes.

EKU Chautauqua Lecture Series "Beauty Matters" presents Dr. Karen Tice (Professor and Chair of UK's Dept. of Gender and Women's Studies and author of Queens of Academe and Tales of Wayward Girls and Immoral Women.

Thursday, Dec 5 at 7:30pm at EKU Campus (O'Donnel Hall, Whitlock Building)

3rd Thursday's Soup & Substance: Real Talk, Real Issues, Real People Series.  A multicultural dialogue and workshop learning series that provides opportunities for peer-to-peer education.  The Martin Luther King Center Emissaries present forums where individuals discuss current events and diversity issues that take place in our world.  This month's topic is Rock the Vote: Do You Know Your Rights? with special guest, Dr. Melynda Price.