Title: Informatics and Modeling Platform for Stable Isotope-Resolve Metabolomics



Abstract: Recent advances in stable isotope-resolved metabolomics (SIRM) are enabling orders-of-magnitude increase in the number of observable metabolic traits (a metabolic phenotype) for a given organism or community of organisms.  Analytical experiments that take only a few minutes to perform can detect stable isotope-labeled variants of thousands of metabolites.  Thus, unique metabolic phenotypes may be observable for almost all significant biological states, biological processes, and perturbations.  Currently, the major bottleneck is the lack of data analysis that can properly organize and interpret this mountain of phenotypic data as highly insightful biochemical and biological information for a wide range of biological research applications.  To address this limitation, we are developing bioinformatic, biostatistical, and systems biochemical tools, implemented in an integrated data analysis platform, that will directly model metabolic networks as complex inverse problems that are optimized and verified by experimental metabolomics data.  This integrated data analysis platform will enable a broad application of SIRM from the discovery of specific metabolic phenotypes representing biological states of interest to a mechanism-based understanding of a wide range of biological processes with particular metabolic phenotypes.

EKU Chautauqua Lecture Series "Beauty Matters" presents Dr. Karen Tice (Professor and Chair of UK's Dept. of Gender and Women's Studies and author of Queens of Academe and Tales of Wayward Girls and Immoral Women.

Thursday, Dec 5 at 7:30pm at EKU Campus (O'Donnel Hall, Whitlock Building)

3rd Thursday's Soup & Substance: Real Talk, Real Issues, Real People Series.  A multicultural dialogue and workshop learning series that provides opportunities for peer-to-peer education.  The Martin Luther King Center Emissaries present forums where individuals discuss current events and diversity issues that take place in our world.  This month's topic is Rock the Vote: Do You Know Your Rights? with special guest, Dr. Melynda Price. 

Join us for an interactive virtual panel featuring people who graduated with degrees in Gender and Women's Studies. 

Based on the book Transforming Scholarship:  Why Women and Gender Studies Students are Changing Themselves and the World

Monday, January 27, 2014 from 2-4pm. 

When Going Home Is Hard:  A Discussion with the VIP Center, Counseling Center, Dean of Students and health services. 

Title:  Some progresses on two-dimensional Riemann problems in gas dynamics

Abstract:  Two dimensional Riemann problems for compressible fluid flows assume the simplest piecewise sectorial initial state but provide the most fundamental wave configurations, including the reflection of oblique shocks and vortex-shock interaction etc. In this talk I will show many fascinating pictures, based on 2D Riemann solutions, to disclose the mysteries of compressible fluid world both through analytical tools (in the form of mathematical theorems) and computational techniques (in the form of simulations). The analysis is based on the characteristic decomposition theory we developed recently, while the simulations are obtained using the generalized Riemann problem (GRP) scheme that is equipped with a highly accurate solver in the construction of numerical fluxes by a way of tracking singularities analytically and keeping entropy exactly computed.