A functional splicing variant associated with decreased asthma risk abolishes the ability of gasdermin B (GSMDB) to induce epithelial cell pyroptosis.
| Author | |
|---|---|
| Abstract | :
Genetic variants in the chromosomal region 17q21 are consistently associated with asthma. However, mechanistic studies have not yet linked any of the associated variants to a function that could influence asthma, and as a result, the identity of the asthma gene(s) remains elusive. |
| Year of Publication | :
2018
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| Journal | :
The Journal of allergy and clinical immunology
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| Date Published | :
2018
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| ISSN Number | :
0091-6749
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| URL | :
http://linkinghub.elsevier.com/retrieve/pii/S0091-6749(18)30023-X
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| DOI | :
10.1016/j.jaci.2017.11.040
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| Short Title | :
J Allergy Clin Immunol
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