Amyloid beta peptide, 4-hydroxynonenal and apoptosis.
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Abstract | :
Considerable evidence suggests a role for oxidative stress in the pathogenesis of neuron degeneration in several neurodegenerative disorders including Alzheimer's disease (AD). Although debated, increasing evidence suggests that oxidative stress/damage (amyloid beta peptide, iron/hydrogen peroxide) or neurotoxic by-products of lipid peroxidation (4-hydroxy-2-nonenal, acrolein) lead to cell death through apoptosis or programmed cell death in AD. This review discusses current evidence supporting the role of oxidative stress/damage mediated apoptosis in in vitro models of neurodegeneration. |
Year of Publication | :
2006
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Journal | :
Current Alzheimer research
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Volume | :
3
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Issue | :
4
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Number of Pages | :
359-64
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ISSN Number | :
1567-2050
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URL | :
https://www.eurekaselect.com/77037/article
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DOI | :
10.2174/156720506778249506
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Short Title | :
Curr Alzheimer Res
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