A new type of DNA "light-switch": a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA.
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| Abstract | :
Ru(bpy)2dppz, a well studied "light-switch" metal complex, transforms into a photochemical "light-switch" and DNA damaging agent by incorporating structural strain. This distorted compound is photoreactive and ejects a ligand upon binding duplex and G-quadruplex DNA, producing a reactive metal center that metalates the DNA. |
| Year of Publication | :
2014
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| Journal | :
Chemical communications (Cambridge, England)
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| Volume | :
50
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| Issue | :
3
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| Number of Pages | :
311-3
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| Date Published | :
2014
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| ISSN Number | :
1359-7345
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| URL | :
https://doi.org/10.1039/c3cc47269h
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| DOI | :
10.1039/c3cc47269h
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| Short Title | :
Chem Commun (Camb)
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