Baraphenazines A-G, Divergent Fused Phenazine-Based Metabolites from a Himalayan Streptomyces.
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Abstract | :
The structures and bioactivities of three unprecedented fused 5-hydroxyquinoxaline/alpha-keto acid amino acid metabolites (baraphenazines A-C, 1-3), two unique diastaphenazine-type metabolites (baraphenazines D and E, 4 and 5) and two new phenazinolin-type (baraphenazines F and G, 6 and 7) metabolites from the Himalayan isolate Streptomyces sp. PU-10A are reported. This study highlights the first reported bacterial strain capable of producing diastaphenazine-type, phenazinolin-type, and izumiphenazine A-type metabolites and presents a unique opportunity for the future biosynthetic interrogation of late-stage phenazine-based metabolite maturation. |
Year of Publication | :
2019
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Journal | :
Journal of natural products
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Volume | :
82
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Issue | :
6
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Number of Pages | :
1686-1693
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Date Published | :
2019
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ISSN Number | :
0163-3864
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URL | :
https://doi.org/10.1021/acs.jnatprod.9b00289
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DOI | :
10.1021/acs.jnatprod.9b00289
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Short Title | :
J Nat Prod
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