A mechanism-based pharmacokinetic model of fenofibrate for explaining increased drug absorption after food consumption.
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Abstract | :
Oral administration of drugs is convenient and shows good compliance but it can be affected by many factors in the gastrointestinal (GI) system. Consumption of food is one of the major factors affecting the GI system and consequently the absorption of drugs. The aim of this study was to develop a mechanistic GI absorption model for explaining the effect of food on fenofibrate pharmacokinetics (PK), focusing on the food type and calorie content. |
Year of Publication | :
2018
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Journal | :
BMC pharmacology & toxicology
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Volume | :
19
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Issue | :
1
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Number of Pages | :
4
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Date Published | :
2018
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DOI | :
10.1186/s40360-018-0194-5
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Short Title | :
BMC Pharmacol Toxicol
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