Independent replication of polymorphisms predicting toxicity in breast cancer patients randomized between dose-dense and docetaxel-containing adjuvant chemotherapy.
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Abstract | :
Although pharmacogenomics has evolved substantially, a predictive test for chemotherapy toxicity is still lacking. We compared the toxicity of adjuvant dose-dense doxorubicin-cyclophosphamide (ddAC) and docetaxel-doxorubicin-cyclophosphamide (TAC) in a randomized multicenter phase III trial and replicated previously reported associations between genotypes and toxicity. |
Year of Publication | :
2017
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Journal | :
Oncotarget
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Volume | :
8
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Issue | :
69
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Number of Pages | :
113531-113542
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Date Published | :
2017
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DOI | :
10.18632/oncotarget.22697
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Short Title | :
Oncotarget
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