NK cells control tumor-promoting function of neutrophils in mice.
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Abstract | :
Although NK cells are recognized as direct antitumor effectors, the ability of NK cells to control cancer-associated inflammation, which facilitates tumor progression, remains unknown. In this study, we demonstrate that NK cells control tumor-promoting inflammation through functional modification of neutrophils. NK cells control the tumor-promoting function of neutrophils through an IFNgamma-dependent mechanism. Tumor progression in an NK cell-depleted host is diminished when the IL17A-neutrophil axis is absent. In NK cell-depleted mice, neutrophils acquire a tumor-promoting phenotype, characterized by up-regulation of VEGF-A expression, which promotes tumor growth and angiogenesis. A VEGFR inhibitor which preferentially suppressed tumor growth in NK cell-depleted mice was dependent on neutrophils. Furthermore, the systemic neutropenia caused by an anti-metabolite treatment showed an anti-cancer effect only in mice lacking NK cells. Thus, NK cells likely control the tumor-promoting and angiogenic function of neutrophils. |
Year of Publication | :
2018
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Journal | :
Cancer immunology research
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Date Published | :
2018
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ISSN Number | :
2326-6066
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URL | :
http://cancerimmunolres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=29362222
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DOI | :
10.1158/2326-6066.CIR-17-0204
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Short Title | :
Cancer Immunol Res
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