Rhodium(I)-Catalyzed Decarbonylative Aerobic Oxidation of Cyclic α-Diketones: A Regioselective Single Carbon Extrusion Strategy.
Author | |
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Abstract | :
A rhodium-catalyzed decarbonylative aerobic oxidation of cyclic α-diketones has been developed for the first time, where the regioselective formations of α-pyrones and isocoumarins have been achieved. The current decarbonylative aerobic oxidation pathway proceeds via the C-C bond cleavage followed by a C-O bond formation, representing a biomimetic oxidation approach to unsaturated six-membered cyclic lactones. The unique ability of rhodium catalysts to induce the decarbonylative aerobic oxidation opens up a new synthetic toolbox that utilizes the "regioselective single carbon" extrusion strategy. |
Year of Publication | :
2018
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Journal | :
Organic letters
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Date Published | :
2018
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ISSN Number | :
1523-7060
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URL | :
https://dx.doi.org/10.1021/acs.orglett.7b03837
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DOI | :
10.1021/acs.orglett.7b03837
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Short Title | :
Org Lett
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