Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model.
| Author | |
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| Abstract | :
We previously demonstrated that positive allosteric modulators (PAMs) of metabotropic glutamate subtype 2 (mGlu2 ) receptors have potential synergistic interactions with the antiseizure drug levetiracetam (LEV). The present study utilizes isobolographic analysis to evaluate the combined administration of JNJ-46356479, a selective and potent mGlu2 PAM, with LEV as well as sodium valproate (VPA) and lamotrigine (LTG). |
| Year of Publication | :
2018
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| Journal | :
Epilepsia
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| Date Published | :
2018
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| ISSN Number | :
0013-9580
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| URL | :
http://dx.doi.org/10.1111/epi.14005
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| DOI | :
10.1111/epi.14005
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| Short Title | :
Epilepsia
|
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