Imaging fibroblast activation protein to monitor therapeutic effects of neutralizing interleukin-22 in collagen-induced arthritis.
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| Abstract | :
RA is a chronic autoimmune disease leading to progressive destruction of cartilage and bone. RA patients show elevated IL-22 levels and the amount of IL-22-producing Th cells positively correlates with the extent of erosive disease, suggesting a role for this cytokine in RA pathogenesis. The purpose of this study was to determine the feasibility of SPECT/CT imaging with 111In-labelled anti-fibroblast activation protein antibody (28H1) to monitor the therapeutic effect of neutralizing IL-22 in experimental arthritis. |
| Year of Publication | :
2018
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| Journal | :
Rheumatology (Oxford, England)
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| Date Published | :
2018
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| ISSN Number | :
1462-0324
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| URL | :
https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/kex456
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| DOI | :
10.1093/rheumatology/kex456
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| Short Title | :
Rheumatology (Oxford)
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